Suicide gene - Wikipedia
A suicide gene, in genetics, will cause a cell to kill itself through apoptosis. Activation of these genes can be due to many processes, but the main cellular "switch" to induce apoptosis is the p53 protein.

Gene that raises suicide risk identified | Science | The ...
Ernest Hemingway (centre) with his family in 1918. Hemingway, two of his siblings and his father (left) committed suicide. Photograph: Reuters Genetic tests on depressed people who tried to take ...

Suicide Gene - an overview | ScienceDirect Topics
Mukesh Kumar, Ambikanandan Misra, in Challenges in Delivery of Therapeutic Genomics and Proteomics, 2011. 6.3.1.1 Suicide Gene Therapy. Suicide gene therapy, also known as gene-directed enzyme prodrug therapy (GDEPT), is the most commonly used approach for solid tumors. The suicide genes, when transduced into target cells, convert inactive prodrugs into cytotoxic metabolites for the host cells.

Suicide Gene Therapy for Cancer – Current Strategies
Suicide gene therapy is a therapeutic strategy, in which cell suicide inducing transgenes are introduced into cancer cells. The two major suicide gene therapeutic strategies currently pursued are: cytosine deaminase/5-fluorocytosine and the herpes simplex virus/ganciclovir.

A Suicide Gene - genomenewsnetwork.org
A Suicide Gene: Is there a genetic cause for suicide? By Sharon Guynup. May 12, 2000. The pattern seems so familiar: a business reversal, the breakup of a marriage, school failure, depression, a downward spiral leading eventually to suicide. The apparent links between failure, depression and suicide have become a cultural icon, appearing over ...

Definition of Suicide gene - MedicineNet
Suicide gene: A gene whose expression in a cell is lethal for that cell. Suicide genes form the basis of a strategy for making cancer cells more vulnerable, more sensitive to chemotherapy.The approach has been to attach parts of genes expressed in cancer cells to other genes for enzymes not found in mammals that can convert a harmless substance into one that is toxic to the tumor.

Is There a Suicide Gene? - The Daily Beast
Is There a Suicide Gene? Depression and bipolar disorder may be in your DNA—but is suicide? Several high-profile families have been plagued by the phenomena.

Suicide Gene Therapy For Treatment: How it Works
Suicide gene therapy is an experimental treatment option with potential as a targeted therapy for mesothelioma, although it is currently available only through clinical trials. In suicide gene therapy, doctors may modify a virus or bacterium, such as E. coli, to safely deliver a cancer-killing gene ...

Suicide Gene Therapy to Increase the Safety of Chimeric ...
Suicide gene therapy with CAR-redirected T cells. Adoptive T-cell therapy with CAR-redirected T lymphocytes is at the frontier of modern cancer treatment 13.The possibility to redirect T cells towards virtually any surface TAA by means of gene therapy, in fact, opens for the exploitation of the extraordinaire therapeutic potential of T cells for an increasing number of patients suffering from ...