Gene duplication - Wikipedia
Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is generated during molecular evolution.It can be defined as any duplication of a region of DNA that contains a gene.Gene duplications can arise as products of several types of errors in DNA replication and repair machinery as well as through fortuitous capture by selfish ...
FGFR2 Gene Amplification - stomachcancertrial.com
FGFR2b Overexpression and FGFR2 Gene Amplification in Patients with Advanced Gastric and GEJ Cancer. About 10% of patients with gastric or gastroesophageal junction (GEJ) cancer have FGFR2 (fibroblast growth factor receptor 2) gene-amplified tumors that overexpress FGFR2b protein.
HER2 Status: Tests, Treatments, and More - breastcancer.org
HER2 (human epidermal growth factor receptor 2) is a gene that can play a role in the development of breast cancer.Your pathology report should include information about HER2 status, which tells you whether or not HER2 is playing a role in the cancer. Genes contain the recipes for the various proteins a cell needs to stay healthy and function normally.
Gene - definition of gene by The Free Dictionary
gene (jēn) n. A hereditary unit consisting of a sequence of DNA that occupies a specific location on a chromosome and is transcribed into an RNA molecule that may function directly or be translated into an amino acid chain. Genes undergo mutation when their DNA sequences change. [German Gen, from gen-, begetting, in Greek words (such as genos, race ...
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Pathology Outlines - HER2 (c-erbB2)
Breast malignant, males, children - HER2 (c-erbB2) HER2 gene amplification / protein overexpression. Present in approximately 15 - 20% of breast tumors Associated with comedocarcinoma and aggressive invasive tumors
Herceptin Dosage Guide - Drugs.com
Patient Selection. Select patients based on HER2 protein overexpression or HER2 gene amplification in tumor specimens [see Indications and Usage (1) and Clinical Studies (14)].Assessment of HER2 protein overexpression and HER2 gene amplification should be performed using FDA-approved tests specific for breast or gastric cancers by laboratories with demonstrated proficiency.
MLL amplification in leukemia - Atlas of Genetics and ...
Duplication or amplification of chromosome band 11q23, including the unrearranged MLL gene, is a recurrent abnormality in therapy-related MDS and AML, and is closely related to mutation of the TP53 gene and to previous therapy with alkylating agents.
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06 March CPT code changes - Quest Diagnostics
CPT Code Changes for Sendout Tests TEST CODE NAME OF TEST CPT CODES IN TRIPLE G NOW CPT CODES CHANGE TO S51015 Alpha Thalassemia Deletion, PCR (11175X) 83890, 83894, 83901, 83912 83891, 83900, 83901x5, 83894, 83912