Editorial: Why DNA sequencing is an effective tool for patient care
In 2012, Mayo Clinic adopted DNA sequencing as a major tool in individualized medicine by using targeted gene panels and whole exome sequencing. We started by looking for actionable targets in patients with advanced cancers (unique features of a tumor that can make one therapeutic drug particularly effective).

Mayo Clinic scientist explains genome sequencing of SARS-CoV-2
This is next-generation sequencing — the process of sequencing DNA or RNA by producing millions of sequence reads in a massively parallel manner. Also known as deep sequencing, next-generation sequencing allows for the sequencing of the entire genome of a microorganism.

Mayo scientists researching 'beyond DNA' to advance personalized ...
Advances in DNA sequencing have also provided infectious diseases diagnostics. With the advent of capillary sequencers in the 1990s, identification of cultured bacteria with 16S ribosomal RNA gene polymerase chain reaction/Sanger sequencing was adopted into clinical practice at Mayo Clinic.

New Mayo Clinic GeneGuide DNA testing application provides genetic ...
ROCHESTER, Minn. — Mayo Clinic released a new DNA product with Helix, a personal genomics company, called "Mayo Clinic GeneGuide." The DNA-powered product provides healthy individuals with genetic testing and insights with a focus on education. This product is backed by Mayo medical science and expertise. “The Mayo Clinic GeneGuide app uses the highest quality […]

Mayo Clinic to sequence 100K participants to build genomic database for ...
ROCHESTER, Minn. — Mayo Clinic is creating a library of genomic sequencing data on 100,000 consented Mayo Clinic participants to advance research and patient care. “We believe that whole exome sequencing has the potential to reveal predispositions to health problems and enable earlier use of preventive measures throughout a person’s lifespan,” says Keith Stewart, M.B., […]

Genomics study enrolls 100,000 participants - Mayo Clinic News Network
The Tapestry DNA Sequencing Research Study — a massive, decentralized clinical research study, aimed to complete exome sequencing of 100,000 Mayo patients and return the results to their electronic health records for three hereditary conditions: familial hypercholesterolemia — a form of high cholesterol; hereditary breast and ovarian cancer ...

Tomorrow’s Cure: How DNA guides cancer detection
This week's podcast episode of Tomorrow's Cure explores how DNA could be used to detect blood cancers before they ever develop. Episode experts include Dr. Mrinal Patnaik , a hematologist, internist and oncologist at Mayo Clinic; and Dr. Kelly Bolton , an oncologist at Washington University in St. Louis.

Mayo Clinic researchers pinpoint genetic variations that might sway ...
ROCHESTER, Minn. — Researchers at Mayo Clinic's Center for Individualized Medicine have discovered key human genomic signatures that could help explain why COVID-19 is severe in some people and mild in others. After analyzing volumes of diverse worldwide DNA sequence data, the scientists identified mutations in two human proteins that might sway the course of […]

Mayo Clinic's largest-ever exome study offers blueprint for biomedical ...
Participants' saliva samples from all three of Mayo Clinic's campuses — in Minnesota, Arizona and Florida — were used to extract DNA for exome sequencing. Exome sequencing analyzes nearly 20,000 genes that provide instructions for making proteins, which play many critical roles in the body.

Exploring the DNA of a strawberry: lessons we can learn about our own ...
Understanding DNA sequencing: how it may improve your health now and in the future Attend the 2017 Individualizing Medicine Conference Hear world-renowned experts discuss the latest research in precision medicine and how it can be applied to improve treatments for many conditions at Individualizing Medicine 2017: Advancing Care Through Genomics .